Technical Advice on seed treatment and Weed control of autumn sowing wheat
issuing time ：2020-11-27
Researchers from the Shenzhen Center for Disease Control and Prevention reported that on March 8, 2020, a citizen in the city suffered from dizziness, nausea, vomiting, limb convulsions and other symptoms after taking a certain drug by mistake. According to the patient's symptoms, it was suspected to be anticoagulant rodenticide or spastic rodenticide poisoning. The municipal CDC laboratory immediately carried out emergency tests on the patient's blood and unknown drugs collected on site, and timely fed the test results back to the medical staff, providing valuable time and scientific basis for the treatment of patients...
At present, the international detection methods of rodenticides mainly include gas chromatography (GC), high performance liquid chromatography (HPLC), gas chromatography-mass spectrometry (GC-MS) and high performance liquid chromatography-mass spectrometry (HPLC-MS/MS). Due to the shortcomings of gas chromatography, high performance liquid chromatography and gas chromatography-mass spectrometry, such as poor ability of accurate qualitative and quantitative, and relatively single detection items, it cannot meet the needs of emergency detection. Considering the timeliness and sensitivity of the emergency test, HPLC-MS/MS was used to detect the suspected rodenticide poisoning samples in the laboratory, and the final quantification was conducted with GC-MS after the suspected rodenticide poisoning was confirmed.
Fluoroacetamide, fluorine sodium acetate and tetramine virulent rodenticide had quite a long time in our country, because of its toxicity is big, and there is no specific antidote, in the early 1990 s by banning the production and use in our country, but because of its deratization effect is good, simple production technology, low cost, therefore, abuse, poisoning occurs frequently, caused serious threat to people's health. The poisoning incident in Shenzhen shows that tetramine is still not extinct in China.
The main mechanism of aminobutyric acid production is inhibition of gamma-aminobutyric acid, blocking the inhibitory neurotransmitter on the neurons, resulting in convulsion. Also can act directly sympathetic nerve, bring about adrenal nerve excitatory symptom and inhibit the activity of certain enzyme. The oral lethal dose (LD50) for mammals is about 0.1mg /kg, and the subcutaneous LD50 for humans is about 0.1mg /kg, and the lethal dose for humans is about 12mg.
Therefore, in case of accidental ingestion of Tetramine, the patient should immediately go to a regular hospital and keep the edible samples, so as to facilitate the laboratory staff to timely take samples for testing, determine the type and edible content of poisons in the first time, and provide accurate and effective treatment plans for medical staff.
At the same time, WeiJian, CDC, love, health and other departments should strengthen the food safety knowledge training for the people, to do a good job of propaganda was used the popular science knowledge, promote the use in accordance with the provisions of the state, safe and effective for chronic rodenticide, strictly prohibited to store your food mixed with rat poison, or toxic drug used in food location was used to properly stored, scientific use, guarantee the safety of people and livestock. Agricultural and rural departments should further strengthen the management of rodenticide, severely crack down on illegal production, transportation, management and use, and consolidate the bottom line of safety protection.